HomeNewsIn cases of suspected intracranial aneurysm or cerebrovascular disease, administering 8 mL of iodinated contrast agent at a rate of 1 mL/s for cerebral CT angiography on a dual-layer spectral detector CT can achieve good diagnostic image quality

In cases of suspected intracranial aneurysm or cerebrovascular disease, administering 8 mL of iodinated contrast agent at a rate of 1 mL/s for cerebral CT angiography on a dual-layer spectral detector CT can achieve good diagnostic image quality

    To assess the possibility of achieving diagnostic quality images using low volume and low flow rate of contrast medium, a preliminary prospective study was conducted on 80 patients with previous subarachnoid hemorrhage and a clinical suspicion of intracranial aneurysm or cerebrovascular diseases undergoing contrast-enhanced cerebral CT angiography (CTA) on a dual-layer spectral detector. Patients were randomly assigned to one of two groups (1:1): one group received intravenous injection of 8 mL of iodinated contrast medium (CM) at a flow rate of 1 mL/s and image analysis was carried out on virtual monoenergetic images at 40-70 keV in addition to conventional images; the control group was administered 40 mL of iodinated CM at a flow rate of 4 mL/s, and image analysis was performed on conventional images alone. Objective and subjective evaluations of image quality, conducted by separate neuroradiologists, demonstrated that the use of an extremely low CM volume (8 mL) and injection rate (4 mL/s) can yield superior contrast-to-noise and signal-to-noise ratios compared to conventional CM volumes and injection rates. Additionally, this approach can provide a clinically satisfactory diagnostic image quality while reducing the risk of adverse events associated with higher CT volumes.