HomeNewsGlomerular filtration rate estimated by measuring contrast medium clearance on contrast-enhanced CT urography demonstrates good agreement with the current reference standard

Glomerular filtration rate estimated by measuring contrast medium clearance on contrast-enhanced CT urography demonstrates good agreement with the current reference standard

    In this retrospective study the glomerular filtration rate (GFR) of 75 kidney donor candidates was assessed on contrast-enhanced CT urography compared with the reference standard of plasma iohexol clearance. For all CT scans, GFR was calculated by evaluating the contrast-medium (CM) excretion rate in the urinary system, and specifically by dividing the HU times mL/min by a surrogate for serum iomeprol concentration in the aorta. The authors demonstrated that the GFR measured on contrast-enhanced CT was precise and unbiased, that the method’s accuracy was good, and the intra-observer concordance was practically perfect. Furthermore, the CT measurements were unaffected by the different CT characteristics and CT scanner equipment.