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Chest CT in COVID-19 patients:
Imaging features and changes in lung appearance

Dear readers,

While the anti-COVID-19 vaccination campaign is progressing efficiently in a large number of
Western countries, new SARS-CoV-2 variants are emerging alarmingly, leading to an escalation in the number of cases and deaths.

In this scenario, the role of chest CT in the identification, monitoring and management of COVID-19 pneumonia remains fundamental. In order to provide a comprehensive overview of CT evidence of COVID-19 pneumonia, we propose a Focus from Professor Laghi’s team where each chest CT imaging finding and pattern related to COVID-19 is analysed accurately and depicted in detail.

The scientific articles selected for this Newsletter illustrate our current knowledge on the dynamic and temporal evolution of chest CT manifestations in COVID-19 patients and discuss the CT imaging similarities with other disease to be considered in the differential diagnosis.

Indeed, the differential diagnosis is the “main theme” of the two clinical cases proposed below, where the clinical and imaging features will help differentiate COVID-19 pneumonia from other conditions characterized by similar CT signs.

As usual, suggestions for topics to be covered in future issues of this newsletter are welcome:
please send your proposals to us at

From the team



Chest CT findings in COVID-19
D. Caruso, E. Lucertini, M. Polici, T. Polidori, A. Laghi
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Zhou Y, Ren H, Wang S et al. The evolution of chest CT findings from admission to follow‑up in 30 moderate to severe adult patients with COVID‑19 pneumonia. Chinese Journal of Academic Radiology. 2021.

Carlicchi E, Gemma P, Poerio A et al. Chest-CT mimics of COVID-19 pneumonia-a review article. Emerg Radiol. 2021 Mar 1;1-12. doi: 10.1007/s10140-021-01919-0. Online ahead of print.

Gu J, Yang L, Li T et al. Temporal relationship between serial RT-PCR results and serial chest CT imaging, and serial CT changes in coronavirus 2019 (COVID-19) pneumonia: a descriptive study of 155 cases in China. Eur Radiol. 2021 Mar;31(3):1175-1184. doi: 10.1007/s00330-020-07268-9. Epub 2020 Sep 15.